Laregab M 100mg/500mcg Tablet is a combination medication containing Gabapentin 100mg and Methylcobalamin 500mcg, indicated primarily for the management of neuropathic pain and peripheral neuropathies. Gabapentin, an anticonvulsant, modulates neuronal excitability by inhibiting voltage-gated calcium channels, thereby reducing abnormal nerve firing and alleviating neuropathic pain symptoms. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair by promoting myelin sheath synthesis and enhancing neuronal metabolism. The synergistic effect of these two agents provides both symptomatic relief and supports nerve healing processes. Laregab M is commonly prescribed for conditions such as diabetic neuropathy, postherpetic neuralgia, and other nerve-related pain syndromes. It is generally well-tolerated, with common adverse effects including dizziness, somnolence, and gastrointestinal disturbances. Dosage should be individualized based on clinical response and tolerability, with careful monitoring in patients with renal impairment due to gabapentin’s renal excretion. This combination offers a comprehensive approach to neuropathic pain management by addressing both symptom control and underlying nerve health, thereby improving patient quality of life. It should be used under medical supervision, considering potential drug interactions and contraindications.