Kuftive-SG Soft Gelatin Capsule is a combination pharmaceutical formulation containing Phenylephrine (5 mg), Chlorpheniramine Maleate (2 mg), and Dextromethorphan Hydrobromide (10 mg). This multi-ingredient capsule is indicated for the symptomatic relief of common cold, allergic rhinitis, and upper respiratory tract infections characterized by nasal congestion, sneezing, runny nose, and cough. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, providing effective vasoconstriction of nasal mucosa blood vessels, thereby reducing nasal congestion. Chlorpheniramine Maleate is a first-generation antihistamine that competitively inhibits H1 histamine receptors, alleviating allergic symptoms such as sneezing and rhinorrhea. Dextromethorphan Hydrobromide serves as a centrally acting antitussive agent, suppressing the cough reflex by acting on the medullary cough center without causing significant sedation. Kuftive-SG is generally well tolerated when used as directed; however, caution is advised in patients with hypertension, glaucoma, or thyroid disorders due to the sympathomimetic effects of Phenylephrine. It is contraindicated in individuals hypersensitive to any component of the formulation. This combination therapy offers a comprehensive approach to managing multiple symptoms associated with upper respiratory conditions, improving patient comfort and quality of life.