Kospride Cream is a topical formulation containing Hydroquinone (2% w/w), Mometasone Furoate (0.1% w/w), and Tretinoin (0.025% w/w), designed for the treatment of hyperpigmentation disorders such as melasma, post-inflammatory hyperpigmentation, and other pigmentary abnormalities. Hydroquinone acts as a skin-lightening agent by inhibiting the enzyme tyrosinase, thereby reducing melanin synthesis and promoting a more even skin tone. Mometasone, a potent corticosteroid, provides anti-inflammatory and immunosuppressive effects, helping to reduce erythema, edema, and irritation associated with pigmentary conditions. Tretinoin, a retinoid derivative, facilitates epidermal cell turnover and enhances the penetration of hydroquinone, while also promoting collagen synthesis and skin renewal. The combination of these three active ingredients offers a synergistic approach to managing hyperpigmentation by targeting melanin production, inflammation, and epidermal regeneration. Kospride Cream should be applied once daily at bedtime to clean, dry skin, avoiding contact with eyes and mucous membranes. Use under medical supervision is recommended due to potential side effects such as skin irritation, dryness, and photosensitivity. Patients should be advised to use sunscreen regularly during treatment to prevent further pigmentation and protect sensitive skin.