Koligesic MF 10mg/250mg Tablet is a combination medication containing Dicyclomine 10mg and Mefenamic Acid 250mg, indicated for the relief of pain associated with gastrointestinal spasms and inflammatory conditions. Dicyclomine is an anticholinergic agent that acts as a smooth muscle relaxant, effectively reducing muscle spasms in the gastrointestinal tract, thereby alleviating abdominal cramps and discomfort. Mefenamic Acid is a nonsteroidal anti-inflammatory drug (NSAID) that provides analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, leading to decreased synthesis of prostaglandins involved in pain and inflammation. The combined action of these two active ingredients makes Koligesic MF suitable for managing conditions such as irritable bowel syndrome, dysmenorrhea, and other painful spasmodic disorders. It should be used under medical supervision, especially in patients with a history of gastrointestinal ulcers, bleeding disorders, renal or hepatic impairment, or hypersensitivity to NSAIDs or anticholinergic agents. Common side effects may include dry mouth, dizziness, nausea, and gastrointestinal discomfort. Patients are advised to follow the prescribed dosage and report any adverse reactions promptly. Koligesic MF should be avoided during pregnancy and lactation unless deemed necessary by a healthcare professional.