Kofwise-CP Tablet is a combination pharmaceutical formulation containing Caffeine (30mg), Diphenhydramine (25mg), Paracetamol (500mg), and Phenylephrine (10mg), designed for the symptomatic relief of common cold, flu, and associated conditions. Paracetamol acts as an analgesic and antipyretic, effectively reducing fever and alleviating mild to moderate pain. Diphenhydramine, a first-generation antihistamine, provides relief from allergic symptoms such as sneezing, runny nose, and watery eyes, while also exerting sedative effects that may aid in improving sleep quality during illness. Phenylephrine serves as a selective alpha-1 adrenergic receptor agonist, promoting vasoconstriction and thereby reducing nasal congestion. Caffeine acts as a central nervous system stimulant, counteracting the sedative effects of diphenhydramine and enhancing alertness. This combination is intended for short-term use to manage multiple symptoms concurrently, improving patient comfort and functionality. Kofwise-CP should be used with caution in individuals with hypertension, cardiovascular disorders, or hypersensitivity to any component. It is contraindicated in patients with severe liver impairment or glaucoma. Dosage should be strictly adhered to as per medical advice to avoid potential adverse effects such as nervousness, insomnia, or gastrointestinal disturbances.