Kligesic S Tablet is a combination medication containing Diclofenac 50 mg and Serratiopeptidase 10 mg, formulated to provide effective relief from pain and inflammation. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and fever. Serratiopeptidase, a proteolytic enzyme, enhances the anti-inflammatory effect by breaking down inflammatory mediators and promoting the resolution of edema and exudates in inflamed tissues. This synergistic combination is particularly beneficial in managing conditions such as musculoskeletal disorders, postoperative inflammation, traumatic injuries, and chronic inflammatory diseases. Kligesic S Tablet is indicated for the relief of acute and chronic pain associated with arthritis, tendonitis, bursitis, and soft tissue injuries. It may also be used adjunctively in postoperative care to reduce swelling and accelerate recovery. The medication should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active gastrointestinal ulcers, bleeding disorders, and severe renal or hepatic impairment. Patients are advised to adhere to prescribed dosages and report any adverse effects, including gastrointestinal discomfort, allergic reactions, or unusual bleeding, to their healthcare provider promptly.