Ketowipe-Plus Cream is a topical formulation combining Ketoconazole (2% w/w), Clioquinol (Iodochlorhydroxyquin) (1% w/w), Tolnaftate (1% w/w), Neomycin (0.1% w/w), and Clobetasol (0.05% w/w) designed for the effective management of mixed fungal and bacterial skin infections accompanied by inflammation. Ketoconazole, a broad-spectrum antifungal agent, inhibits ergosterol synthesis, disrupting fungal cell membrane integrity. Clioquinol exhibits antifungal and antibacterial properties, enhancing the spectrum of antimicrobial activity. Tolnaftate contributes additional antifungal efficacy, particularly against dermatophytes. Neomycin, an aminoglycoside antibiotic, targets susceptible bacterial pathogens, reducing secondary bacterial infections. Clobetasol, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, thereby alleviating erythema, swelling, and itching associated with dermatoses. Ketowipe-Plus Cream is indicated for conditions such as tinea infections complicated by bacterial superinfection and inflammatory dermatoses requiring combined antifungal, antibacterial, and corticosteroid therapy. The cream should be applied topically to the affected area once or twice daily as prescribed, avoiding prolonged use to minimize potential corticosteroid-related adverse effects. Caution is advised in patients with hypersensitivity to any component, and it is contraindicated in viral or tubercular skin infections. Proper medical supervision is recommended to ensure safe and effective use.