Ketoven-Plus 5 Cream is a topical formulation combining Ketoconazole (2.0% w/w), Clioquinol (Iodochlorhydroxyquin) (1.0% w/w), Tolnaftate (1.0% w/w), Neomycin (0.10% w/w), and Clobetasol (0.05% w/w) designed for the effective management of mixed fungal and bacterial skin infections accompanied by inflammatory dermatoses. Ketoconazole, an imidazole antifungal agent, inhibits ergosterol synthesis, disrupting fungal cell membrane integrity, while Clioquinol exhibits broad-spectrum antimicrobial activity against fungi and certain bacteria. Tolnaftate contributes additional antifungal efficacy, particularly against dermatophytes. Neomycin, an aminoglycoside antibiotic, targets susceptible bacterial pathogens, reducing secondary bacterial infections. Clobetasol, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, alleviating erythema, swelling, and itching associated with dermal infections. The synergistic combination ensures comprehensive treatment of complex dermatological conditions such as tinea infections complicated by bacterial superinfection and inflammatory responses. Ketoven-Plus 5 Cream should be applied topically as directed by a healthcare professional, typically once or twice daily, with treatment duration tailored to clinical response. Caution is advised due to the presence of clobetasol; prolonged use may lead to skin atrophy, systemic absorption, or corticosteroid-related adverse effects. It is contraindicated in viral infections, hypersensitivity to components, and should be used under medical supervision.