Ketorol SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100 mg), Paracetamol (325 mg), and Serratiopeptidase (15 mg). Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory and analgesic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides effective analgesia and antipyretic action through central inhibition of prostaglandin synthesis, complementing the peripheral effects of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation by enhancing fibrinolytic activity. This synergistic combination is indicated for the management of acute musculoskeletal pain, postoperative pain, dental pain, and inflammatory conditions such as arthritis and soft tissue injuries. Ketorol SP Tablet offers rapid and sustained relief from pain and inflammation, improving patient comfort and mobility. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active gastrointestinal ulcers, bleeding disorders, and severe hepatic or renal impairment. Caution is advised in patients with cardiovascular risk factors. The dosage and duration of therapy should be individualized to minimize adverse effects while optimizing therapeutic outcomes.