Ketonate Cream is a topical formulation combining Ketoconazole 2% w/w, Beclometasone 0.025% w/w, and Neomycin 0.5% w/w, designed for the treatment of inflammatory fungal and bacterial skin infections. Ketoconazole, an imidazole antifungal agent, exhibits broad-spectrum activity against dermatophytes, yeasts, and some molds by inhibiting ergosterol synthesis, essential for fungal cell membrane integrity. Beclometasone, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, reducing redness, swelling, and discomfort associated with inflammatory dermatoses. Neomycin, an aminoglycoside antibiotic, offers bactericidal action against susceptible gram-negative and some gram-positive bacteria by inhibiting protein synthesis. The combination is particularly effective in managing mixed infections where fungal and bacterial pathogens coexist alongside inflammatory skin conditions such as eczema complicated by secondary infection or seborrheic dermatitis with bacterial superinfection. Ketonate Cream should be applied topically to the affected area once or twice daily, as directed by a healthcare professional, ensuring the skin is clean and dry prior to application. Prolonged use should be avoided to reduce the risk of corticosteroid-related adverse effects and antibiotic resistance. Patients should be monitored for potential hypersensitivity reactions, and use is contraindicated in viral or mycobacterial skin infections.