Ketol-Z Lotion is a topical formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, designed for the treatment of various dermatological conditions caused by fungal and bacterial infections. Ketoconazole, an imidazole antifungal agent, exerts its effect by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. Zinc Pyrithione possesses antibacterial and antifungal properties, effectively reducing the proliferation of microbes on the skin surface and alleviating symptoms such as itching, scaling, and inflammation. Ketol-Z Lotion is indicated for the management of seborrheic dermatitis, dandruff, pityriasis versicolor, and other superficial fungal infections. The combination of these active ingredients provides a broad-spectrum antimicrobial action, enhancing therapeutic efficacy while minimizing the risk of resistance. The lotion formulation ensures ease of application and rapid absorption, promoting patient compliance. Ketol-Z Lotion should be applied topically to the affected area once or twice daily as directed by a healthcare professional. It is contraindicated in patients with known hypersensitivity to ketoconazole, zinc pyrithione, or any excipients. Use with caution in pregnant or lactating women. Adverse effects are generally mild and may include local irritation or dryness.