Ketokem Shampoo is a medicated topical formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, indicated for the treatment of dandruff, seborrheic dermatitis, and other fungal infections of the scalp. Ketoconazole, an imidazole antifungal agent, exerts its effect by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting fungal growth and replication. Zinc Pyrithione possesses antibacterial and antifungal properties, reducing scalp flaking, itching, and inflammation associated with seborrheic conditions. The combined action of these active ingredients provides a broad-spectrum approach to managing scalp disorders caused by Malassezia species and other pathogenic fungi. Ketokem Shampoo is typically applied to wet hair and scalp, massaged gently to form a lather, left in place for 3 to 5 minutes to allow adequate contact time, and then rinsed thoroughly. Regular use as directed by a healthcare professional can effectively control symptoms and prevent recurrence. Caution is advised in patients with known hypersensitivity to ketoconazole, zinc pyrithione, or any shampoo excipients. Avoid contact with eyes; if accidental exposure occurs, rinse thoroughly with water. Ketokem Shampoo should be used under medical supervision, especially in pediatric and pregnant populations.