Ketofresh Active Cream is a topical formulation combining Ketoconazole (2% w/w), Beclometasone (0.025% w/w), and Neomycin (0.5% w/w), designed for the effective management of mixed fungal and bacterial skin infections accompanied by inflammation. Ketoconazole, a broad-spectrum antifungal agent, inhibits ergosterol synthesis, disrupting fungal cell membrane integrity and thereby treating dermatophytic and yeast infections. Beclometasone, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, reducing erythema, swelling, and discomfort associated with inflammatory dermatoses. Neomycin, an aminoglycoside antibiotic, offers antibacterial activity against susceptible gram-negative and some gram-positive organisms, preventing or controlling secondary bacterial infections. The synergistic combination in Ketofresh Active Cream is particularly beneficial in conditions such as infected eczema, dermatitis, and tinea with secondary bacterial colonization. It is intended for topical application to affected areas, ensuring localized action with minimal systemic absorption. Caution is advised in prolonged use due to potential corticosteroid-related side effects and the risk of antibiotic resistance. Ketofresh Active Cream should be used under medical supervision, avoiding application on open wounds or mucous membranes, and discontinued if hypersensitivity reactions occur. This formulation provides a comprehensive therapeutic approach for complex dermatological infections requiring antifungal, anti-inflammatory, and antibacterial intervention.