Ketofine Lotion is a topical antifungal formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, indicated for the treatment of various superficial fungal infections of the skin. Ketoconazole, an imidazole antifungal agent, acts by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. Zinc Pyrithione exhibits broad-spectrum antimicrobial activity, including antifungal and antibacterial effects, and is effective in reducing inflammation and scaling associated with dermatological conditions. The combination of these active ingredients provides a synergistic effect, making Ketofine Lotion effective against dermatophytes, yeasts such as Malassezia species, and other pathogenic fungi responsible for conditions like tinea versicolor, seborrheic dermatitis, and pityriasis capitis. Ketofine Lotion is applied topically to the affected area once or twice daily as directed by a healthcare professional. It is generally well tolerated; however, mild local irritation or itching may occur. Patients should avoid contact with eyes and mucous membranes. The product is contraindicated in individuals with known hypersensitivity to any of its components. Ketofine Lotion should be used under medical supervision to ensure appropriate diagnosis and treatment.