Ketofine Cream contains Ketoconazole 2% w/w, a broad-spectrum antifungal agent effective against a variety of dermatophytes, yeasts, and molds. It is primarily indicated for the topical treatment of superficial fungal infections such as tinea corporis, tinea cruris, tinea pedis, and pityriasis versicolor. Ketoconazole exerts its antifungal activity by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. The cream formulation allows for targeted application to affected skin areas, ensuring localized therapeutic effect while minimizing systemic absorption and associated adverse effects. Ketofine Cream is typically applied once or twice daily to the affected area and surrounding skin after cleansing and drying, with treatment duration varying depending on the infection type and severity, generally ranging from 2 to 4 weeks. It is contraindicated in patients with known hypersensitivity to ketoconazole or any cream excipients. Common adverse reactions may include mild local irritation, burning, or itching at the application site. Patients are advised to avoid contact with eyes and mucous membranes and to discontinue use if severe irritation occurs. Ketofine Cream should be used under medical supervision to ensure appropriate diagnosis and treatment monitoring.