Ketoff Lotion is a topical formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, indicated for the treatment of various dermatological conditions characterized by fungal and seborrheic involvement. Ketoconazole, an imidazole antifungal agent, exhibits broad-spectrum activity against dermatophytes, yeasts, and molds by inhibiting ergosterol synthesis, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. Zinc Pyrithione possesses antibacterial and antifungal properties, effectively reducing the proliferation of Malassezia species and other microorganisms implicated in seborrheic dermatitis and dandruff. Ketoff Lotion is primarily used in managing seborrheic dermatitis, pityriasis versicolor, and other superficial fungal infections of the skin. The combined action of Ketoconazole and Zinc Pyrithione provides enhanced efficacy in reducing inflammation, scaling, itching, and erythema associated with these conditions. It is applied topically to the affected area once or twice daily as directed by a healthcare professional. Patients should avoid contact with eyes and mucous membranes. Use during pregnancy and lactation should be under medical supervision. Adverse effects are generally mild and may include local irritation or dryness. Ketoff Lotion offers an effective therapeutic option for fungal and seborrheic skin disorders when used as prescribed.