Ketoff Cream contains Ketoconazole 2% w/w, an imidazole antifungal agent effective in the treatment of various superficial fungal infections. Ketoconazole acts by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. This topical formulation is indicated for the management of dermatophytosis, candidiasis, pityriasis versicolor, and seborrheic dermatitis. Ketoff Cream is applied directly to the affected area once or twice daily, depending on the severity and type of infection, and should be used for the full prescribed duration to prevent recurrence. It is well tolerated, with minimal systemic absorption, reducing the risk of systemic side effects. Common local adverse reactions may include mild irritation, burning sensation, or erythema at the application site, which are generally transient. Ketoff Cream should not be used in patients with known hypersensitivity to ketoconazole or any of the cream’s excipients. Caution is advised when applying near the eyes or mucous membranes. This medication is intended for topical use only and should not be ingested. Proper hygiene and adherence to treatment guidelines enhance therapeutic outcomes and minimize the risk of fungal resistance.