Ketoclean Shampoo is a medicated topical formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, indicated for the treatment of dandruff, seborrheic dermatitis, and other scalp conditions associated with fungal infections and excessive flaking. Ketoconazole, an imidazole antifungal agent, exerts its effect by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting fungal growth and proliferation. Zinc Pyrithione possesses antibacterial and antifungal properties, contributing to the reduction of scalp inflammation, itching, and scaling. The synergistic combination of these active ingredients provides effective control of Malassezia species, commonly implicated in dandruff and seborrheic dermatitis pathogenesis. Ketoclean Shampoo is suitable for use in adults and adolescents and is applied topically to the affected scalp areas, typically used two to three times weekly for optimal results. It is important to follow the prescribed duration of treatment to prevent recurrence. The formulation is generally well tolerated; however, mild local irritation or dryness may occur. Patients should avoid contact with eyes and mucous membranes. Ketoclean Shampoo offers a comprehensive therapeutic approach for managing scalp fungal conditions, improving symptoms, and restoring scalp health.