Ketafung-Z Plus Lotion is a topical antifungal formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, indicated for the treatment of various superficial fungal infections of the skin. Ketoconazole, an imidazole derivative, exhibits broad-spectrum antifungal activity by inhibiting ergosterol synthesis, a critical component of fungal cell membranes, leading to increased membrane permeability and cell death. Zinc Pyrithione possesses antibacterial and antifungal properties, effectively reducing fungal proliferation and inflammation, making it particularly useful in managing seborrheic dermatitis and dandruff. The combination of these active ingredients provides a synergistic effect, enhancing therapeutic efficacy against dermatophytes, yeasts, and Malassezia species. Ketafung-Z Plus Lotion is typically applied once or twice daily to the affected area after cleansing, ensuring adequate coverage and absorption. It is well tolerated, with minimal risk of systemic absorption or adverse effects when used as directed. Caution is advised in patients with known hypersensitivity to either component. This product is contraindicated on mucous membranes and broken skin. Ketafung-Z Plus Lotion offers an effective option for managing fungal skin infections, promoting symptom relief and restoration of healthy skin flora.