Kayavate S Lotion is a topical dermatological formulation containing Clobetasol propionate 0.05% w/w, a potent corticosteroid, combined with Salicylic Acid 3% w/w, a keratolytic agent. This combination is indicated for the management of various inflammatory and hyperkeratotic skin conditions such as psoriasis, eczema, and dermatitis. Clobetasol propionate exerts strong anti-inflammatory, immunosuppressive, and antiproliferative effects by inhibiting multiple inflammatory cytokines and mediators, thereby reducing redness, swelling, and itching. Salicylic Acid facilitates the removal of scales and promotes exfoliation by softening keratin, enhancing the penetration and efficacy of the corticosteroid. Kayavate S Lotion is typically applied once or twice daily to the affected areas, avoiding contact with eyes and mucous membranes. It is intended for short-term use under medical supervision due to the risk of potential side effects associated with potent corticosteroids, including skin atrophy, telangiectasia, and hypothalamic-pituitary-adrenal axis suppression if overused. Patients should adhere strictly to prescribed duration and dosage. This formulation offers an effective therapeutic option for controlling symptoms and improving skin appearance in chronic inflammatory dermatoses with hyperkeratotic features.