K2-Ziv Shampoo is a medicated topical formulation containing Ketoconazole 2% w/v and Zinc Pyrithione 1% w/v, designed for the treatment of various scalp conditions characterized by fungal and microbial involvement. Ketoconazole, an imidazole antifungal agent, exerts its effect by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting fungal growth and proliferation. Zinc Pyrithione possesses antifungal, antibacterial, and anti-inflammatory properties, contributing to the reduction of scalp flaking, itching, and inflammation commonly associated with dandruff and seborrheic dermatitis. K2-Ziv Shampoo is indicated for the management of dandruff, seborrheic dermatitis, and pityriasis versicolor, providing symptomatic relief and addressing the underlying fungal etiology. The combination of Ketoconazole and Zinc Pyrithione offers a synergistic effect, enhancing therapeutic efficacy. The shampoo should be applied to the affected scalp area, left in contact for several minutes to ensure adequate penetration, and rinsed thoroughly. Regular use as directed by a healthcare professional is essential for optimal results. K2-Ziv Shampoo is generally well tolerated; however, patients should be advised to avoid contact with eyes and discontinue use if irritation or hypersensitivity occurs. Consultation with a healthcare provider is recommended before initiating treatment, especially in cases of extensive or refractory scalp conditions.