Jonac 100mg Suppository contains Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) indicated for the management of mild to moderate pain and inflammation associated with conditions such as musculoskeletal disorders, postoperative pain, and dysmenorrhea. Diclofenac exerts its therapeutic effect by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. The suppository formulation allows for rapid absorption through the rectal mucosa, providing an alternative route of administration for patients who experience difficulty with oral intake or require localized drug delivery. Jonac 100mg Suppository is typically administered rectally, with dosage and duration tailored according to the severity of symptoms and patient response. It is contraindicated in patients with hypersensitivity to diclofenac, aspirin, or other NSAIDs, as well as those with active gastrointestinal bleeding, severe hepatic or renal impairment, and certain cardiovascular conditions. Caution is advised in patients with a history of gastrointestinal ulcers or bleeding, and concurrent use with other NSAIDs or anticoagulants should be avoided to minimize adverse effects. Common side effects may include gastrointestinal discomfort, nausea, and local irritation at the site of administration. Patients should consult healthcare professionals before use to ensure appropriate indication and dosing.