Javanerve-NT Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channel function to reduce neuronal excitability and alleviate neuropathic pain symptoms. Nortriptyline, a tricyclic antidepressant, enhances noradrenaline and serotonin neurotransmission, contributing to analgesic effects and improving mood disturbances often accompanying chronic neuropathic pain. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by facilitating myelin sheath synthesis and promoting neuronal health. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing peak-related adverse effects. Javanerve-NT is indicated for diabetic neuropathy, post-herpetic neuralgia, peripheral neuropathies, and other neuropathic pain syndromes. It is contraindicated in patients with hypersensitivity to any component, recent myocardial infarction, or severe cardiac conduction abnormalities. Common adverse effects may include dizziness, dry mouth, somnolence, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, and dose adjustments may be necessary. This combination therapy offers a multimodal approach targeting pain modulation, mood stabilization, and nerve repair, enhancing overall clinical outcomes in neuropathic pain management.