Ivagesic-SP Tablet is a combination analgesic formulation containing Diclofenac 50 mg, Paracetamol 325 mg, and Serratiopeptidase 10 mg, designed for the effective management of pain and inflammation. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol complements this action through central analgesic and antipyretic mechanisms, providing symptomatic relief from mild to moderate pain and fever. Serratiopeptidase, a proteolytic enzyme, enhances the anti-inflammatory effect by breaking down inflammatory mediators and promoting the resolution of edema and tissue repair. Ivagesic-SP is indicated for the treatment of musculoskeletal disorders, postoperative pain, dental pain, and other inflammatory conditions where pain relief and reduction of swelling are desired. The synergistic combination ensures rapid onset and sustained relief with improved tolerability compared to higher doses of individual agents. Caution is advised in patients with hepatic, renal, or gastrointestinal impairment, and it should be used under medical supervision to minimize potential adverse effects such as gastrointestinal irritation, hypersensitivity reactions, or bleeding tendencies. Ivagesic-SP Tablet offers a balanced therapeutic approach for effective pain and inflammation management.