Itraset 100 Capsule contains Itraconazole 100 mg, a broad-spectrum antifungal agent belonging to the triazole class. It is indicated for the treatment of various systemic and superficial fungal infections caused by susceptible fungi, including dermatophytes, yeasts, and molds. Itraconazole exerts its antifungal effect by inhibiting the cytochrome P450-dependent enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol, a critical component of fungal cell membranes. Disruption of ergosterol synthesis leads to increased membrane permeability and ultimately fungal cell death. Itraset 100 Capsule is commonly prescribed for conditions such as onychomycosis, aspergillosis, histoplasmosis, blastomycosis, and candidiasis. It is administered orally, with absorption enhanced when taken with food. Caution is advised in patients with hepatic impairment or congestive heart failure, and potential drug interactions should be carefully reviewed due to itraconazole’s effect on cytochrome P450 enzymes. Adverse effects may include gastrointestinal disturbances, headache, rash, and, rarely, hepatotoxicity. Regular monitoring of liver function tests is recommended during prolonged therapy. Itraset 100 Capsule should be used under medical supervision, adhering strictly to prescribed dosages to ensure efficacy and minimize resistance development.