Itraduo 100 Capsule contains Itraconazole 100 mg, a broad-spectrum triazole antifungal agent used for the treatment of various systemic and superficial fungal infections. Itraconazole acts by inhibiting the fungal cytochrome P450 enzyme 14α-demethylase, which is essential for the conversion of lanosterol to ergosterol, a critical component of the fungal cell membrane. This disruption leads to increased membrane permeability and ultimately fungal cell death. Itraduo 100 is indicated for the management of infections such as aspergillosis, blastomycosis, histoplasmosis, onychomycosis, and other dermatophytic infections. It is also effective against candidiasis, including oropharyngeal and esophageal candidiasis. The capsule formulation allows for convenient oral administration with improved bioavailability when taken with food. Dosage should be individualized based on the type and severity of infection, and treatment duration may vary from weeks to several months. Caution is advised in patients with hepatic impairment, and liver function tests should be monitored periodically. Itraconazole has potential drug interactions due to its effect on cytochrome P450 enzymes; therefore, concomitant use with certain medications should be avoided or closely monitored. Common adverse effects include gastrointestinal disturbances, headache, and rash. Itraduo 100 Capsule should be used under medical supervision to ensure efficacy and safety.