Itazo-KT Tablet is a combination pharmaceutical formulation containing Ketoprofen 50 mg and Thiocolchicoside 4 mg, indicated for the management of musculoskeletal pain and associated inflammatory conditions. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and fever. Thiocolchicoside, a muscle relaxant with anti-inflammatory properties, acts as a selective antagonist of GABA and glycine receptors, leading to the relief of muscle spasms and improvement of mobility. The combination of these agents provides synergistic efficacy in alleviating acute and chronic musculoskeletal disorders such as low back pain, osteoarthritis, rheumatoid arthritis, and muscle strains. Itazo-KT is typically administered orally, with dosage and duration tailored to the severity of symptoms and patient response. Caution is advised in patients with a history of gastrointestinal ulcers, renal or hepatic impairment, and hypersensitivity to NSAIDs or colchicine derivatives. Common adverse effects may include gastrointestinal discomfort, dizziness, and allergic reactions. Itazo-KT should be used under medical supervision, considering contraindications and potential drug interactions to ensure optimal therapeutic outcomes.