It-Zest 200 Capsule contains Itraconazole 200 mg, a broad-spectrum triazole antifungal agent used for the treatment of various systemic and superficial fungal infections. Itraconazole acts by inhibiting the cytochrome P450-dependent enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol, a key component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately fungal cell death. It-Zest 200 is indicated for the management of infections such as aspergillosis, blastomycosis, histoplasmosis, onychomycosis, and candidiasis, including oropharyngeal and esophageal candidiasis. The capsule formulation ensures adequate bioavailability when taken with food, enhancing absorption. Dosage and duration of therapy should be individualized based on the type and severity of infection, patient response, and clinical judgment. It is contraindicated in patients with hypersensitivity to itraconazole or other azole antifungals and should be used cautiously in individuals with hepatic impairment or congestive heart failure due to potential adverse effects. Common side effects include gastrointestinal disturbances, headache, and rash. Drug interactions are significant due to itraconazole’s inhibition of CYP3A4 enzymes, necessitating careful review of concomitant medications. Monitoring liver function tests during prolonged therapy is recommended to detect hepatotoxicity early.