IT Mac SB 130mg Capsule contains Itraconazole 130mg, a broad-spectrum triazole antifungal agent indicated for the treatment of various fungal infections. Itraconazole exerts its antifungal effect by inhibiting the cytochrome P450-dependent enzyme lanosterol 14-α-demethylase, which is essential for ergosterol synthesis, a key component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately fungal cell death. IT Mac SB 130mg Capsule is effective against a wide range of pathogenic fungi, including dermatophytes, yeasts such as Candida species, and molds like Aspergillus. It is commonly prescribed for conditions such as onychomycosis, blastomycosis, histoplasmosis, aspergillosis, and other systemic and superficial mycoses. The capsule formulation allows for convenient oral administration with improved bioavailability when taken with food. Dosage and duration of therapy depend on the type and severity of the infection and should be determined by a healthcare professional. Caution is advised in patients with hepatic impairment or congestive heart failure, and potential drug interactions should be reviewed prior to initiation. Common adverse effects include gastrointestinal disturbances, headache, and rash. Regular monitoring of liver function tests is recommended during prolonged therapy to ensure patient safety.