IT-Mac 100 Capsule contains Itraconazole 100 mg, a broad-spectrum triazole antifungal agent effective against a variety of fungal infections. Itraconazole works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting cell membrane integrity and leading to fungal cell death. IT-Mac 100 is indicated for the treatment of systemic and superficial mycoses, including blastomycosis, histoplasmosis, aspergillosis, onychomycosis, and other dermatophytic infections. It is particularly useful in patients who are intolerant or refractory to other antifungal therapies. The capsule formulation ensures optimal bioavailability when taken with food, enhancing absorption. Dosage and duration of therapy depend on the type and severity of infection, and treatment should be guided by clinical response and laboratory findings. Caution is advised in patients with hepatic impairment or congestive heart failure, and potential drug interactions must be carefully monitored due to itraconazole’s inhibition of cytochrome P450 enzymes. Common adverse effects include gastrointestinal disturbances, headache, and rash. Regular liver function tests are recommended during prolonged therapy. IT-Mac 100 Capsule should be prescribed and administered under medical supervision to ensure safety and efficacy.