Inmeth 100mg Suppository contains Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID) used primarily for its potent anti-inflammatory, analgesic, and antipyretic properties. Indomethacin exerts its effect by inhibiting the cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which play a key role in inflammation, pain, and fever. Inmeth 100mg Suppository is indicated for the management of moderate to severe pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, and acute musculoskeletal injuries. The suppository form is particularly beneficial for patients who experience gastrointestinal intolerance to oral NSAIDs or have difficulty swallowing tablets. Upon rectal administration, Indomethacin is absorbed systemically, providing effective symptom relief while minimizing gastrointestinal side effects commonly associated with oral administration. Dosage and duration of therapy should be individualized based on the severity of symptoms and patient response, with caution advised in patients with a history of peptic ulcers, renal impairment, or cardiovascular disease. Common adverse effects may include gastrointestinal discomfort, headache, dizziness, and rarely, renal dysfunction. Inmeth 100mg Suppository should be used under medical supervision, with regular monitoring to ensure safety and efficacy.