Indosom 75 Capsule SR contains Indomethacin 75 mg, a nonsteroidal anti-inflammatory drug (NSAID) used primarily for its analgesic, anti-inflammatory, and antipyretic properties. Indomethacin exerts its effect by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which play a key role in inflammation and pain. This sustained-release formulation ensures a gradual release of the active ingredient, providing prolonged therapeutic effects and improved patient compliance by reducing dosing frequency. Indosom 75 Capsule SR is indicated for the management of various inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis. It is also effective in treating moderate to severe pain and inflammation associated with musculoskeletal disorders. The medication should be used under medical supervision, particularly in patients with a history of gastrointestinal ulcers, cardiovascular disease, renal or hepatic impairment, as NSAIDs may exacerbate these conditions. Common adverse effects include gastrointestinal discomfort, nausea, headache, and dizziness. Caution is advised when administered concomitantly with anticoagulants, corticosteroids, or other NSAIDs. Regular monitoring and adherence to prescribed dosage are essential to minimize risks and optimize therapeutic outcomes.