Imprex-MN Tablet SR is a sustained-release formulation combining Pregabalin 75 mg, Nortriptyline 10 mg, and Methylcobalamin 1500 mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and seizures. Nortriptyline, a tricyclic antidepressant, inhibits the reuptake of norepinephrine and serotonin, contributing to analgesic effects and mood stabilization in chronic pain syndromes. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and enhancing neuronal function. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and symptom control. Imprex-MN is indicated for diabetic neuropathy, post-herpetic neuralgia, and other neuropathic pain disorders, offering a multimodal approach by targeting different pathophysiological pathways. The combination therapy may also benefit patients with concomitant depressive symptoms due to the antidepressant effect of Nortriptyline. Caution is advised in patients with renal impairment, cardiac conditions, or a history of seizures. Common adverse effects include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Use under medical supervision is recommended to optimize dosing and monitor for potential drug interactions or side effects.