Ibugesic Plus Tablet is a combination analgesic and antipyretic formulation containing Ibuprofen 400 mg and Paracetamol 325 mg, designed for the effective management of mild to moderate pain and fever. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins responsible for inflammation, pain, and fever. Paracetamol (acetaminophen) acts centrally to inhibit prostaglandin synthesis, providing analgesic and antipyretic benefits without significant anti-inflammatory activity. The synergistic action of these two agents offers enhanced pain relief compared to monotherapy, making Ibugesic Plus suitable for conditions such as musculoskeletal pain, dental pain, headache, postoperative pain, and febrile episodes. It is generally well tolerated when used as directed; however, caution is advised in patients with a history of gastrointestinal ulcers, renal or hepatic impairment, and hypersensitivity to NSAIDs or paracetamol. The medication should be administered with food to minimize gastrointestinal discomfort. Dosage adjustments may be necessary in special populations, and prolonged use should be avoided unless supervised by a healthcare professional. Ibugesic Plus Tablet provides a balanced approach to pain and fever management, combining rapid onset and sustained relief.