Ibugesic Plus Oral Suspension Orange is a combination analgesic and antipyretic formulation containing Ibuprofen 100 mg and Paracetamol 162.5 mg per 5 ml. This suspension is indicated for the relief of mild to moderate pain and fever associated with conditions such as headache, dental pain, musculoskeletal discomfort, and common cold symptoms. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its effect by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for inflammation, pain, and fever. Paracetamol acts centrally to elevate the pain threshold and reduce fever through inhibition of prostaglandin synthesis in the central nervous system. The combination provides enhanced analgesic efficacy by targeting multiple pain pathways while minimizing the dose-related adverse effects associated with each individual component. Ibugesic Plus Oral Suspension is suitable for pediatric use, with dosing adjusted according to age and weight, and the pleasant orange flavor improves palatability and compliance. It is contraindicated in patients with hypersensitivity to ibuprofen, paracetamol, or other NSAIDs, as well as those with active gastrointestinal bleeding or severe hepatic or renal impairment. Caution is advised in patients with asthma, cardiovascular disease, or coagulation disorders. Use under medical supervision is recommended to ensure safe and effective treatment.