I Glow Night Cream contains a combination of Hydroquinone (2% w/w), Tretinoin (0.025% w/w), and Fluocinolone acetonide (0.01% w/w), formulated for the treatment of hyperpigmentation disorders such as melasma, post-inflammatory hyperpigmentation, and other pigmentary abnormalities. Hydroquinone acts as a skin-lightening agent by inhibiting tyrosinase, thereby reducing melanin synthesis and promoting gradual fading of dark spots. Tretinoin, a retinoid derivative, facilitates increased epidermal cell turnover and enhances the penetration of hydroquinone, contributing to improved skin texture and tone. Fluocinolone acetonide, a mild corticosteroid, helps to reduce inflammation and irritation commonly associated with retinoid and hydroquinone use, improving tolerability and patient compliance. This combination therapy should be applied topically at night to clean, dry skin, avoiding contact with eyes and mucous membranes. Patients are advised to use sunscreen during the day due to increased photosensitivity. Use is generally recommended under medical supervision, as inappropriate use may cause adverse effects such as skin irritation, erythema, or steroid-induced dermatitis. I Glow Night Cream provides a synergistic approach to managing pigmentary disorders, promoting a more even and radiant complexion with consistent use.