Horfenac-TH4 Tablet is a combination medication containing Aceclofenac 100 mg and Thiocolchicoside 4 mg, formulated for the management of pain and inflammation associated with musculoskeletal disorders. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for inflammation, pain, and swelling. Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic properties, acting as a selective antagonist of GABA and glycine receptors, which helps alleviate muscle spasms and stiffness. The combination of these two agents provides synergistic relief from conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute musculoskeletal pain including strains and sprains. Horfenac-TH4 is typically prescribed to improve patient mobility and quality of life by reducing pain and muscle tension. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, peptic ulcer disease, and certain cardiovascular conditions. Common adverse effects may include gastrointestinal discomfort, dizziness, and allergic reactions. Patients are advised to follow prescribed dosages and report any unusual symptoms promptly to their healthcare provider.