Histoglob 1ml Injection is a sterile preparation containing Human Normal Immunoglobulin (12mg), Histamine Dihydrochloride (0.15mcg), and Sodium Thiosulphate (32mg), formulated for immunomodulatory therapy. Human Normal Immunoglobulin provides passive immunity by supplying a broad spectrum of antibodies derived from pooled human plasma, aiding in the enhancement of the recipient’s immune response against various pathogens. Histamine Dihydrochloride acts as an immunostimulant by modulating immune cell activity, particularly enhancing natural killer (NK) cell function and improving the efficacy of immunoglobulin-mediated immune responses. Sodium Thiosulphate serves as an antioxidant and stabilizing agent, protecting the formulation and potentially mitigating oxidative stress during immune activation. Histoglob is indicated for use in conditions requiring immunoglobulin supplementation, such as immunodeficiency disorders, certain infections, and as an adjunct in immunotherapy protocols. The injection should be administered intramuscularly or intravenously under strict aseptic conditions, with dosage and frequency determined by clinical indication and patient response. Caution is advised in patients with known hypersensitivity to immunoglobulin preparations or any component of the formulation. Adverse effects may include mild local reactions, hypersensitivity, or systemic allergic responses. Proper storage and handling are essential to maintain product efficacy and safety.