Histabil M Tablet contains a combination of Bilastine 20 mg and Montelukast 10 mg, formulated to provide effective relief from allergic conditions. Bilastine is a second-generation antihistamine that selectively antagonizes peripheral H1 receptors, thereby reducing symptoms such as sneezing, nasal congestion, rhinorrhea, and itching associated with allergic rhinitis and urticaria. Montelukast is a leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor, contributing to the reduction of inflammation, bronchoconstriction, and mucus production commonly observed in asthma and allergic rhinitis. The synergistic action of these two agents makes Histabil M Tablet suitable for managing seasonal and perennial allergic rhinitis, chronic urticaria, and mild to moderate asthma symptoms. The combination offers a dual mechanism by targeting both histaminergic and leukotriene pathways, enhancing symptom control and improving patient quality of life. Histabil M is generally well tolerated; common adverse effects may include headache, gastrointestinal discomfort, and fatigue. It is recommended to be taken once daily, preferably in the evening, with or without food. Caution is advised in patients with hepatic impairment or hypersensitivity to any component. Consultation with a healthcare professional is essential before initiating therapy to ensure appropriate use and monitoring.