Hexab Emulsion is a topical formulation containing Lindane 1% w/v and Cetrimide 0.1% w/v, indicated for the treatment of ectoparasitic infestations such as scabies and pediculosis. Lindane, an organochlorine compound, exerts potent neurotoxic effects on parasites by disrupting their gamma-aminobutyric acid (GABA)-mediated neurotransmission, leading to paralysis and death of mites and lice. Cetrimide, a quaternary ammonium antiseptic, enhances the antimicrobial efficacy of the preparation by providing bactericidal and cleansing properties, thereby reducing secondary bacterial infections commonly associated with parasitic skin conditions. Hexab Emulsion is applied topically to the affected areas, ensuring thorough coverage to maximize therapeutic outcomes. It is essential to follow recommended application guidelines to minimize systemic absorption and potential neurotoxicity, particularly in pediatric and elderly populations. The emulsion base facilitates uniform distribution and skin penetration while maintaining skin hydration. Hexab Emulsion is contraindicated in individuals with hypersensitivity to Lindane, Cetrimide, or any formulation excipients. Caution is advised in patients with pre-existing neurological disorders. Adverse effects may include localized irritation, pruritus, erythema, and rarely systemic toxicity if misused. Proper patient education on application and avoidance of overuse is critical to ensure safety and efficacy.