Halgesic S Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 10 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), provides effective relief from pain and inflammation by inhibiting cyclooxygenase enzymes involved in prostaglandin synthesis. Paracetamol acts as an analgesic and antipyretic, enhancing pain relief and reducing fever through central inhibition of prostaglandin production. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of swelling and edema, thereby improving tissue healing and reducing discomfort. This combination is indicated for the management of acute musculoskeletal pain, osteoarthritis, rheumatoid arthritis, postoperative pain, and other inflammatory conditions. Halgesic S Tablet offers a synergistic effect by targeting multiple pathways involved in pain and inflammation, providing rapid and sustained symptomatic relief. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active peptic ulcer, or severe hepatic or renal impairment. Caution is advised in patients with cardiovascular risk factors. The dosage and duration of therapy should be tailored to the individual patient’s clinical condition to maximize efficacy and minimize adverse effects.