Gretacal Injection is a sterile, parenteral formulation combining Calcium Gluconate (50 mg) and Calcium Lactobionate (87.5 mg) designed to address hypocalcemia and related calcium deficiencies. This dual-calcium preparation facilitates rapid correction of serum calcium levels in patients experiencing acute calcium depletion due to conditions such as hypoparathyroidism, vitamin D deficiency, or during calcium channel blocker overdose. Calcium Gluconate serves as a bioavailable source of elemental calcium, essential for maintaining neuromuscular function, cardiac contractility, and bone metabolism, while Calcium Lactobionate enhances calcium solubility and stability, ensuring efficient systemic absorption. Gretacal Injection is indicated for intravenous administration under strict medical supervision, enabling prompt restoration of calcium homeostasis and prevention of complications such as tetany, cardiac arrhythmias, and muscle spasms. The formulation is particularly useful in emergency settings requiring immediate intervention. Dosage and administration should be individualized based on patient’s serum calcium levels, clinical status, and underlying etiology. Caution is advised in patients with hypercalcemia, renal impairment, or those receiving digitalis therapy due to potential adverse effects. Monitoring of serum calcium and electrolytes during treatment is recommended to avoid hypercalcemia and associated toxicity. Gretacal Injection is a vital therapeutic agent in managing calcium imbalances in diverse clinical scenarios.