Glz Total Tablet

Glz Total Tablet
Gliclazide (60mg) + Pioglitazone (15mg) + Metformin (500mg)
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About This Medicine
Product description & overview
Glz Total Tablet is a combination oral hypoglycemic agent containing Gliclazide 60 mg, Pioglitazone 15 mg, and Metformin 500 mg, indicated for the management of type 2 diabetes mellitus. This formulation synergistically improves glycemic control through complementary mechanisms of action. Gliclazide, a sulfonylurea, stimulates pancreatic beta-cell insulin secretion, thereby reducing blood glucose levels. Pioglitazone, a thiazolidinedione, enhances peripheral insulin sensitivity by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), promoting glucose uptake in adipose and muscle tissues. Metformin, a biguanide, primarily decreases hepatic gluconeogenesis and improves insulin sensitivity, contributing to reduced fasting and postprandial glucose concentrations. The combination is particularly beneficial for patients inadequately controlled on monotherapy or dual therapy, offering improved efficacy with a lower risk of hypoglycemia compared to sulfonylurea monotherapy. Glz Total Tablet should be administered as prescribed by a healthcare professional, with dosage adjustments based on glycemic response and tolerance. Caution is advised in patients with renal or hepatic impairment, heart failure, or a history of lactic acidosis. Regular monitoring of blood glucose, renal function, and liver enzymes is recommended during therapy. This combination therapy supports comprehensive glycemic management in type 2 diabetes, aiming to reduce the risk of long-term complications.
Active composition
Pioglitazone 15 mg
+2 more active ingredients
About Pioglitazone
Pioglitazone is an antidiabetic medication used to treat type 2 diabetes. It works by improving insulin sensitivity and regulating blood sugar levels. Pioglitazone is effective in managing diabetes. In summary, Pioglitazone is beneficial for treating type 2 diabetes.
How It Works
Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-γ), enhancing insulin sensitivity and glucose metabolism.
All Active Ingredients
Gliclazide
Gliclazide stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues.
Metformin
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
It is unsafe to consume alcohol with Glz Total Tablet.
High Risk
Pregnancy
Glz Total Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Driving
Glz Total Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Exercise Caution
Liver
Glz Total Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Regular Checkup
Breastfeeding
Glz Total Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Kidney
Glz Total Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Regular Checkup
Customer Reviews
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