Gluconorm G2 Forte Tablet PR is a combination oral hypoglycemic agent containing Glimepiride 2mg and Metformin 1000mg, formulated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class drug, stimulates pancreatic beta cells to release insulin, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, enhancing glucose uptake by muscle tissues. The prolonged-release (PR) formulation ensures a steady release of active ingredients, promoting better glycemic control with reduced dosing frequency and minimizing gastrointestinal side effects commonly associated with metformin. Gluconorm G2 Forte is indicated for patients inadequately controlled on diet and exercise alone or those requiring combination therapy to achieve optimal glycemic targets. It is essential to monitor blood glucose levels regularly and adjust dosage based on therapeutic response and tolerance. This medication should be used cautiously in patients with renal impairment, hepatic dysfunction, or conditions predisposing to hypoxia. Contraindications include type 1 diabetes, diabetic ketoacidosis, and hypersensitivity to any component. Adherence to prescribed regimens, along with lifestyle modifications such as diet and exercise, is critical for effective diabetes management and prevention of complications.