Gluconorm-G Plus 2 Tablet PR is a combination oral antihyperglycemic medication containing Glimepiride 2 mg and Metformin 850 mg, indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, stimulates pancreatic beta cells to enhance insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production, improving peripheral insulin sensitivity, and enhancing glucose uptake in muscle tissues. The synergistic action of these agents provides effective reduction of blood glucose levels in patients inadequately controlled by diet and exercise alone. Gluconorm-G Plus 2 Tablet PR is typically prescribed as part of a comprehensive diabetes management plan, including lifestyle modifications such as diet and physical activity. It is important to monitor blood glucose levels regularly to adjust the dosage and minimize the risk of hypoglycemia, particularly due to the sulfonylurea component. Caution is advised in patients with renal impairment, hepatic dysfunction, or conditions predisposing to lactic acidosis. Common adverse effects may include gastrointestinal disturbances, hypoglycemia, and rarely, lactic acidosis. This medication should be used under medical supervision with appropriate patient education on recognizing hypoglycemia symptoms and adherence to prescribed therapy.