Gluconorm-G Plus 1 Tablet PR is a combination oral hypoglycemic agent containing Glimepiride 1mg and Metformin 850mg, indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class drug, stimulates pancreatic beta cells to increase insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production and enhancing peripheral insulin sensitivity, resulting in improved glucose uptake and utilization. The sustained-release formulation ensures a gradual release of active ingredients, promoting better glycemic control with reduced gastrointestinal side effects commonly associated with immediate-release metformin. Gluconorm-G Plus 1 Tablet PR is prescribed as an adjunct to diet and exercise to achieve optimal blood glucose levels in patients inadequately controlled by either agent alone or when combination therapy is deemed appropriate. It is essential to monitor blood glucose levels regularly and adjust dosage based on therapeutic response and tolerability. Caution is advised in patients with renal or hepatic impairment, cardiovascular disease, or conditions predisposing to hypoglycemia. Common adverse effects may include hypoglycemia, gastrointestinal disturbances, and rare instances of lactic acidosis. This medication should be used under medical supervision with appropriate lifestyle modifications for effective diabetes management.