Glospor SB 65 Capsule contains Itraconazole 65 mg, an antifungal agent belonging to the triazole class, indicated for the treatment of a variety of fungal infections. Itraconazole exerts its antifungal effect by inhibiting the cytochrome P450-dependent enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol, a critical component of fungal cell membranes. Disruption of ergosterol synthesis leads to increased membrane permeability and ultimately fungal cell death. Glospor SB 65 is effective against infections caused by dermatophytes, yeasts, and molds, including conditions such as onychomycosis, blastomycosis, histoplasmosis, aspergillosis, and candidiasis. The capsule formulation allows for oral administration, with absorption enhanced when taken with food. It is important to adhere to prescribed dosing regimens to ensure therapeutic efficacy and minimize resistance development. Caution is advised in patients with hepatic impairment or congestive heart failure, and potential drug interactions should be reviewed due to itraconazole’s inhibition of cytochrome P450 enzymes. Common adverse effects include gastrointestinal disturbances, headache, and rash. Glospor SB 65 Capsule should be used under medical supervision, with monitoring of liver function recommended during prolonged therapy.