Glisen MF Forte 1 Tablet is a combination oral antidiabetic medication containing Glimepiride 1mg and Metformin 1000mg, indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, enhances pancreatic beta-cell insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily reduces hepatic glucose production and increases peripheral insulin sensitivity, contributing to improved glucose uptake and utilization. The synergistic action of these agents effectively lowers blood glucose levels, aiding in the control of hyperglycemia in patients inadequately managed by diet and exercise alone. Glisen MF Forte is typically prescribed when monotherapy with either agent is insufficient. It is essential to initiate therapy with appropriate lifestyle modifications including diet and exercise. The medication should be taken with meals to minimize gastrointestinal side effects commonly associated with Metformin, such as nausea, diarrhea, and abdominal discomfort. Regular monitoring of blood glucose, renal function, and potential adverse effects is recommended during treatment. Caution is advised in patients with renal impairment, hepatic dysfunction, or cardiovascular disease. Glisen MF Forte is contraindicated in patients with known hypersensitivity to its components, diabetic ketoacidosis, or severe renal insufficiency. Adherence to prescribed dosage and medical supervision is critical to optimize therapeutic outcomes and minimize risks.