Glimestar-PM2 Tablet ER
Glimestar-PM2 Tablet ER
Glimepiride (2mg) + Metformin (500mg) + Pioglitazone (15mg)
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About This Medicine
Product description & overview
Glimestar-PM2 Tablet ER is a combination oral antidiabetic medication containing Glimepiride 2mg, Metformin 500mg, and Pioglitazone 15mg, formulated as an extended-release tablet to provide sustained glycemic control in patients with type 2 diabetes mellitus. Glimepiride, a sulfonylurea, enhances pancreatic insulin secretion, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, contributing to better glycemic regulation without causing significant hypoglycemia. Pioglitazone, a thiazolidinedione, acts as an insulin sensitizer by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), improving glucose uptake in adipose tissue and muscle. The combination therapy targets multiple pathophysiological defects of type 2 diabetes, offering improved efficacy over monotherapy. Glimestar-PM2 is indicated for patients inadequately controlled on diet, exercise, and monotherapy with either agent. The extended-release formulation allows once-daily dosing, enhancing patient compliance. Caution is advised in patients with hepatic or renal impairment, congestive heart failure, or a history of bladder cancer due to pioglitazone’s risk profile. Common adverse effects include gastrointestinal disturbances, hypoglycemia, and weight gain. Regular monitoring of blood glucose, liver function tests, and cardiovascular status is recommended during therapy.
Active composition
Metformin 500 mg
+2 more active ingredients
About Metformin
Metformin is an oral antihyperglycemic agent used to manage type 2 diabetes mellitus. It works by decreasing glucose production in the liver and improving insulin sensitivity. Metformin is effective in controlling blood sugar levels and preventing diabetes-related complications. In summary, Metformin is vital for managing type 2 diabetes.
How It Works
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
All Active Ingredients
Glimepiride
Glimepiride stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues, facilitating glucose uptake and lowering blood sugar levels.
Pioglitazone
Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-γ), enhancing insulin sensitivity and glucose metabolism.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
It is unsafe to consume alcohol with Glimestar-PM2 Tablet ER.
High Risk
Pregnancy
Glimestar-PM2 Tablet ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Driving
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Exercise Caution
Liver
Glimestar-PM2 Tablet ER should be used with caution in patients with liver disease. Dose adjustment of Glimestar-PM2 Tablet ER may be needed. Please consult your doctor. Use of Glimestar-PM2 Tablet ER is not recommended in patients with severe liver disease.
Regular Checkup
Breastfeeding
Glimestar-PM2 Tablet ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Kidney
Glimestar-PM2 Tablet ER should be used with caution in patients with kidney disease. Dose adjustment of Glimestar-PM2 Tablet ER may be needed. Please consult your doctor. Use of Glimestar-PM2 Tablet ER is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Regular Checkup
Customer Reviews
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