Glenfenac-SP Forte Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100 mg), Paracetamol (325 mg), and Serratiopeptidase (15 mg). This formulation is designed to provide effective relief from pain and inflammation associated with musculoskeletal disorders, osteoarthritis, rheumatoid arthritis, and post-operative or post-traumatic conditions. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Paracetamol acts centrally to alleviate pain and reduce fever through inhibition of prostaglandin synthesis in the central nervous system. Serratiopeptidase is a proteolytic enzyme that facilitates the breakdown of inflammatory mediators, promoting the resolution of edema and enhancing tissue repair. The synergistic action of these three components makes Glenfenac-SP Forte effective in managing moderate to severe pain with an anti-inflammatory effect while minimizing the need for higher doses of individual agents, thereby potentially reducing adverse effects. It is recommended to use this medication under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active peptic ulcers, or severe hepatic or renal impairment. Proper dosing and adherence to prescribed duration are essential to maximize therapeutic benefits and minimize risks.